Gudmundur Thordarson

The University of Texas at El Paso, USA

Gudmundur Thordarson received the Ph.D. degree from the University of Reading, UK, in 1984, and did the postdoctoral training at the University of California Santa Cruz, Santa Cruz, CA, USA, from 1984 to 1988. Thordarson is at the present time an Associate Professor at the Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA. Thordarson's research interest during the research career has been in reproductive endocrinology and lately with more emphasis on hormonal regulation of breast cancer development and progression. The following are three research areas Thordarson is currently pursuing: (1) investigating what changes are seen in gene expression when breast cancers progress from a state of estrogen-dependent growth to estrogen independence. For these studies Thordarson has used the MNU-induced rat mammary cancer model. Mammary cancer tissues from MNU-treated intact animals and ovariectomized animals have been used to carry out microarray analysis to determine global changes in gene expression of mammary tumors when they progress from hormone-dependent to hormone-independent state. (2) The second parameter is studying the hormonal regulation of the estrogen receptor (ER) in ER-positive breast cancers emphasizing the importance of the GH/IGF-I axis in this regulation using different breast cancer cell lines. (3) Finally, Thordarson is interested in analyzing human breast tissue and blood to gain a better understanding of changes associated with the parity-related breast cancer protection of early pregnancy in women. In previous work in this area, Thordarson has found that changes in the hormonal environment associated with parity may be a key factor in the parity-associated protection against breast cancer.

Biography Updated on 31 January 2013

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