Jeffrey A. Frelinger

University of North Carolina at Chapel Hill, USA


Work in our laboratory is focused on understanding how T cells and MHC molecules function in the immune response to pathogens. This simple question involves the most fundamental aspect of immunology: self/non-self discrimination. Our work uses a wide variety of biophysical, biochemical and immunological approaches. We have focused our attention on the initiation of the immune response- how infections, trauma, and age impact the innate and adaptive response. We use a variety of systems, to address this problem. At the same time we are fascinated by the role of T cell in autoimmunity. We work on the role of T cells in Type 1 Diabetes. We are interested in developing therapies that will allow us to selectively delete autoimmune, but not normal T cells from mice and humans with Type 1 Diabetes. We are working in both NOD mice and in humanized mice to use novel technologies including toxin coupled MHC-multimers and novel molded nanoparticles to accomplish this goal. As biology moves into attempts to understand more complex relationships we expect that we will devote more of our time to systems biology approaches to understand how different parts of the host response react to the environment.

Biography Updated on 11 December 2008

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