Cristina Grange

University of Torino, Italy


Cristina Grange graduated in medical biotechnology in 2004 at the University of Turin (110/110 cum laude). Grange obtained the Ph.D. degree in medical pathophysiology in 2007 with a thesis entitled “Endothelial Differentiation of Human Mammary Tumor Stem Cells.” Grange is the author of 49 scientific publications in international journals and 3 chapters in scientific books (h-index is 24, calculated for ten years using “Scopus” website). Grange’s research was initially focused on the characterization and on the role of tumor endothelial cells and cancer stem cell population from human renal cell carcinoma and from breast tumor, demonstrating the ability of cancer stem cells to differentiate in vitro and in vivo into endothelial cells, participating in the vasculogenesis process. Based on her consolidated experience in the field of stem cells, especially of cancer stem cells, Grange has studied the biological role of extracellular vesicle shed by renal cancer stem cells in terms of advantage of tumor progression and metastasization in vitro and in vivo. Grange characterized the content of extracellular vesicles in terms of proteins and RNAs (mRNAs and miRNAs). The results of this project better explain the biology of human renal carcinoma and hypothesize the formation of a premetastatic niche, induced by factors released by primary tumor. In parallel, Grange has strong experience in the study of the role of extracellular vesicle released from mesenchymal stem cells (MSCs) of different origins in several mouse models of renal damage, monitoring their biodistribution by optical imaging in vivo.

Biography Updated on 28 August 2018

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