Giuseppe Manco

National Research Council, Italy

Giuseppe Manco was born in Capua, Italy, in 1962. In 1987, he obtained the degree in biological sciences (magna cum laude) with a dissertation in physiology at the University of Naples Federico II and in 1988 the specialization in biochemical technologies and the qualification to exert the profession of biologist at the same University. After some years of fellowships at the National Research Council (CNR) of Italy at the International Institute of Genetic and Biophysics in 1994, he became a nonpermanent Researcher at the Institute of Protein Biochemistry, CNR, Naples. In 1995, he was a Visiting Scientist at the National Institute of Health of Bethesda, USA. In 1997, Dr. Manco obtained a permanent position as a Researcher and in 2001 as a Senior Researcher at the Institute of Protein Biochemistry. From 2002 to 2009, he served as an Elected Member of the Institute Committee. Dr. Manco is the leader of a group involved in the study of the structure-function relationship in enzymes from the viewpoint of understanding the determinants that underlay (thermal) stability and the molecular processes which control the substrate recognition, enzyme inhibition, and enzyme catalysis. These tasks are approached by studying enzymes from (hyper)thermophilic sources, mainly from Archaea, and are also performed by comparison with mesophilic, homologous counterparts, which allow tracing back evolution of enzyme activity by looking at sequence/structure hallmarks and promiscuous activities. Furthermore, the potential uses of these enzymes in the industry, for the environment and for human health, are investigated. Since 2004, Dr. Manco was on the Editorial Review Board of Archaea.

Biography Updated on 11 August 2009

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