Paul J. Grippo

Northwestern University, USA

Paul J. Grippo is currently an Assistant Research Professor at the Department of Surgery at Northwestern University in Chicago, ill, USA. He received his Ph.D. degree in animal sciences from the University of Wisconsin in Madison and a postdoctoral fellowship at the Medical College of Wisconsin. His primary research interests include designing, generating, and employing mouse models of pancreatic cancer in order to establish (1) a means of early detection, (2) improved understanding of disease development and causative events, and (3) effective chemopreventive and/or therapeutic strategies. His laboratory utilizes pancreatic cancer cells and tissue as well as normal human pancreas cells as models to explore events involved in pancreatic carcinogenesis and correlate these findings with both mouse and human tissue. These systems have been employed in studies examining the effects of increased exposure to omega-3 and omega-6 fatty acids, indicating common threads from these various genes in relationship to changes in cell signaling pathways and surrounding cell compartments, including mesenchymal and adipose cells. Since dietary consumption of fatty acids can affect these compartments, Dr. Grippo has two related projects looking at the roles Tgfbr1 and PEDF play in pancreatic neoplasia and cancer. Current mouse studies are being evaluated using high power MRI, a technology that is capable of detecting cell and tissue changes in mouse pancreas with potential ramifications as an early detection modality with clinical value. Dr. Grippo is a past recipient of an AACR-Pancreatic Cancer Action Network career development award and served as a Chairman for the Mouse Models of Human Cancer Minisymposium as part of the AACR 2012 Annual Meeting.

Biography Updated on 17 February 2013

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