Jean-Pierre Louboutin

Thomas Jefferson University, USA

Jean-Pierre Louboutin holds M.D. and Ph.D. degrees and serves as a neurologist being interested in the neuropathogenesis of HIV-1. By developing different animal models of HIV-1 associated neurocognitive disorder (HAND), he focused his work on the deleterious effects of HIV-1 envelope glycoprotein gp120 and nonstructural protein Tat in the brain (apoptosis, oxidative stress, neuroinflammation, abnormalities of the blood-brain barrier, upregulation of MMPs). SV40-mediated gene delivery of antioxidant enzymes SOD1 and GPx1 assessed in different experimental settings, protected neurons against gp120- and Tat-induced apoptosis, and other harmful effects. Another field of interest is viral-based gene transfer/gene therapy in different tissues (i.e., bone marrow stem cells, skeletal muscle) and its interaction with regenerative medicine in a translational context. He serves as the Author of about 80 papers in peer-reviewed journals.

Biography Updated on 29 January 2012

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