J.Paul.G. Malthouse

University College Dublin, Ireland


Paul Malthouse studied biochemistry at Queen Elizabeth College, London, UK, in 1973. He used stopped-flow to study the mechanism of the thiol proteases papain and ficin with Professor Keith Brocklehurst. He was awarded a Ph.D. degree in biochemistry from the University of London, London, UK, in 1977. His initial postdoctoral studies were with Professor Brocklehurst (1977–1978). He then worked with Professor R.C. Bray at the University of Sussex, East Sussex, UK, using EPR and rapid quenching techniques to investigate the mechanism of xanthine oxidase (1978–1980). With Professor I. Scott at Edinburgh (1980–1983) and Texas A&M University (1983–1985), he developed cryoenzymological techniques for studying catalytic intermediates by NMR. In 1985, he was appointed as a College Lecturer at University College Dublin, a Senior Lecturer (1996–1998), and a Professor in 1998. His early work at UCD concentrated on specificity studies on pyridoxal phospate-dependent enzymes, catalytic antibodies, enzyme-catalyzed synthesis, beta lactoglobulins, and 13C-NMR studies on chloromethylketone inhibitor derivates of the serine proteinases. Recently, he has focussed on looking at the reversible inhibition of serine, cysteine, and aspartyl proteinases as well as metalloproteinases. Proteases studied include chymotrypsin, trypsin, subtilisin, papain, pepsin,beta-secretase, thermolysin, and stromelysin. He was the Head of the Biochemistry Department (2002–2005) and the Head of Subject for Biochemistry (2006–2008). He was awarded UCD President’s research fellowships in 1990 and 2008 as well as the Irish National Committee for Biochemistry Award Medal for 1997. In 2005, he was elected as a Member of the Royal Irish Academy. In 2009, he had 210 publications (71 full papers, 23 communications, 8 review articles, and 108 posters/abstracts). Biography Updated on 24 March 2009

Biography Updated on 27 April 2009

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