Wendy Hanna-Rose

Pennsylvania State University, USA

Wendy Hanna-Rose serves as an Associate Professor of biochemistry and molecular biology and an Associate Department Head for undergraduate studies. Hanna-Rose received the B.A. degree from Anderson University, the Ph.D. degree from Harvard University, and the Postdoc degree from University of Colorado at Boulder. Hanna-Rose is a Member of the Society for Developmental Biology (SDB), Genetics Society of America (GSA), and American Society of Cell Biology (ASCB). The overarching goal of the Hanna-Rose lab is to understand how development is genetically programmed. They use the development of the reproductive structures in the nematode Caenorhabditis elegans as a research model. Their research is focused in the following two areas. (1) NAD metabolism: NAD+ is a central molecule in metabolism and a cosubstrate for NAD+ consuming enzymes that regulate key biological processes, such as longevity and stress responses. While the biochemistry of NAD+ biosynthesis from vitamin B3 is well studied, the biological impacts of disruption of this biosynthetic pathway in a multicellular organism are not. They have made the novel discovery that elimination of the first enzyme in the NAM to NAD+ salvage biosynthesis pathway (PNC-1) causes developmental and functional defects in the reproductive system. They aim to understand how perturbation of metabolism and/or NAD+ consumer activity during development contributes to reproductive function. (2) Tubulogenesis: the cell rearrangements contributing to tubulogenesis in different organs and even within different areas of a single biological tube vary. They aim to understand molecular mechanisms directing the development of biological tubes. By studying C. elegans vulval tubulogenesis, they recently revealed a novel mechanism for de novo lumen formation involving migration of one cell through an epithelial cell layer, and they developed a model that requires phospholipase function for maintenance of this luminal space. Current research is aimed at testing this model.

Biography Updated on 26 August 2012

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