Gabriela Da Silva Xavier

Imperial College London, United Kingdom


Gabriela Da Silva Xavier completed her Ph.D. degree in biochemistry at the University of Bristol, Bristol, UK, with Professor A. Rutter, in 2001, where she worked on how glucose regulates insulin release and gene expression in the pancreatic beta-cell through its effects on the fuel sensors AMP-activated protein kinase (AMPK) and PAS-domain protein kinase (PASK). In 2005, after two postdoctoral positions where she continued to work on fuel sensing kinases that regulate pancreatic beta-cell function (with Professor Rutter) and then on the role of a glucose-sensitive transcription factor, carbohydrate responsive element binding protein (ChREBP; with Dr. I. Leclerc) in the same cell type. She received a fellowship from the Juvenile Diabetes Research Foundation to elucidate how the fuel sensor PASK may be involved in glucose sensing in the beta-cell. In the same year, she received an Albert Renold Travelling Fellowship from the European Foundation for the Study of Diabetes to study how PASK may be involved in pancreatic endocrine cell development with Dr. Raphael Scharfmann (Inserm, Paris). She moved to Imperial College in 2006 where she continued to study the role of PASK in pancreatic endocrine cell function and development and was involved in collaborative efforts to elucidate how the Type 2 Diabetes genes identified by Genome Wide Association Studies, such as TCF7L2, SLC30A8, WFS1, and HHEX, may affect beta-cell function and development. Currently, she is also working on a project to determine whether long-term administration of the GLP-1 receptor agonist, exendin 4, may induce pancreatitis and pancreatic cancer.

Biography Updated on 31 March 2013

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