Michal A. Rahat

Technion-Israel Institute of Technology, Israel


Michal Amit Rahat received her B.A. and M.S. degrees from the Department of Biology, and her D.S. degree in clinical biochemistry from the Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel, in 1985, 1988, and 1992, respectively. She then became a Postdoctoral Fellow at the Department of Internal Medicine in the Carmel Medical Center, Haifa, Israel, where she studied the effects of intestinal ischemia and reperfusion on TNFa production in remote organs. Since then, she studied the effects of ischemia in different in vivo models and its in vitro simulation by hypoxia on the proinflammatory response, especially their regulatory effects on molecules such as TNFa, nitric oxide, MMPs and TIMPs, and antigen-presenting molecules, in both endothelial cells and in monocytes/macrophages. Currently, she studies the role of macrophages in angiogenesis, tissue repair, and invasiveness/metastasis in the context of solid tumors or inflammatory diseases, as manifested by the aforementioned effector molecules. In particular, she focuses on the regulation of MMPs and VEGF by EMMPRIN, and the regulation of NO, TNFa, EMMPRIN, and other molecules by microRNA. She currently serves as an Assistant Professor at the Faculty of Medicine, Technion-Israel Institute of Technology, and as the Head of the Immunology Research Unit at the Carmel Medical Center.

Biography Updated on 1 January 2013

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