Shintaro Iwashita received the Ph.D. degree from The University of Tokyo in 1975 on the study of the host specificity of Salmonella phage adsorption (under the supervisor of Dr. Shiro Kanegasaki). He has been working on the roles of plasma membrane such as on fibronectin (Tokyo Metropolitan Institute of Medical Science: Dr. Ichiro Yahara), on transformation mechanism of Rous sarcoma virus (The Cancer Institute of Japan Foundation of Cancer Research: Dr. Mitsuaki Yoshida), on EGF receptor signaling (University of California at Los Angeles: Dr. C. Fred Fox), and on Ras GTPase activating protein in Mitsubishi Kagaku Institute of Life Sciences (as a group leader, 1986–2006). During the study, he found a novel type of gene family, named Bcnt after Bucentaur, which were created by gene duplication followed by retrotransposon insertion. The two paralogs result in the recruitment of AP-endonuclease domain of ruminant-specific retrotransposon. He moved to the Faculty of Pharmacy, Iwaki Meisei University as a Professor of the Department of Biochemistry in 2007. Since mammalian AP-endonuclease is one of the major regulators of cellular responses to various stresses, he has proposed that the recruited AP-endonuclease domains may be utilized by the paralogs in cellular regulation and thought that the Bcnt family members provide a good opportunity to examine dynamic changes in signaling networks.
Biography Updated on 17 October 2011