Tuan Huy Nguyen
POSITIONS HELD: Since 2012: Research Associate (CR1) INSERM U1064, Dr. Ignacio Anegon, Nantes, France Head of a research group in Team 2 for cell and gene therapy of inherited liver disorders Head of a in-house Platform of Genetic engineering and vectorology http://www.itun.nantes.inserm.fr/index.php/en/ 2006-2011: Research Associate (CR1) INSERM U948, Dr. Nicolas Ferry, Nantes, France 2002-2006: Senior Research Associate, Department of Molecular Medicine, D. TRONO, Geneva 2000-2002: Post-doctoral fellowship, Department of Molecular Medicine, Pr. Didier TRONO, Geneva 1996-1999: Graduate student, INSERM U380, Dr. Anne Weber, ICGM, Paris, FRANCE MAIN DOMAIN OF RESEARCH: Crigler-Najjar disease, Liver gene therapy, Vectorology, Gene editing, Regenerative medecine, IPS NGUYEN TH has long been interested in Crigler Najjar disease as a paradigm for setting up strategies of cell and gene therapy for inherited liver diseases. He has developed the SLIT protocol, in which hepatocytes are transduced in Suspension with Lentiviral vectors and Immediately Transplanted. SLIT was validated in the Gunn rat, in SCID mice with hepatocytes isolated from a Crigler-Najjar patient, combined to a surgical technique to improve cell engraftment (liver embolization) and was scaling-up to larger animal models: nonhuman primate animal and Watanabe rabbit (familial hypercholesterolemia). As an alternative source of hepatocytes, he is developing induced pluripotent stem cells. In parallel, he has developed novel lentiviral vectors and surgical technique (isolated liver) for in vivo gene therapy of the Gunn rat. For both cell and gene therapy, he is now developing ZFNs/TALENs mediated-genome editing strategies.
Biography Updated on 10 March 2013