Carlos Sevcik

Venezuelan Institute for Scientific Research, Venezuela

Carlos Sevcik, M.D., D.Sc., is a Professor Emeritus at the Center for Biophysics and Biochemistry, Venezuelan Institute for Scientific Research (IVIC), in Caracas, Venezuela. His scientific interests span from numerical models of living systems, chaos and dynamic systems, to the mechanism of action and pharmacokinetics (PK) of venoms and antivenoms, specially scorpion venoms. His recent publications deal with the fractal analysis of venom complexity, new antibiotic and antineoplastic peptides from scorpion venoms, and the PK of scorpion venoms and antivenoms. His work has shown that antivenoms of the F(ab')2 type are actively extruded from blood to tissues at high rates, and has provided quantitative PK of these antivenoms in humans and in animal models. Antivenoms must often be administered under non ideal conditions where the iv route is not available due to skill or patient conditions. This motivates his interest on antivenom PK when other routes are used. He got an M.D. at the Carabobo University, Venezuela, and a D.Sc. in Biophysics and Physiology, at the graduate school (CEA) of IVIC. A postdoctoral fellowship under Prof. Toshio Narahashi, Physiology and Pharmacology Department, Medical School, Duke University, NC, USA, motivated his interest in toxins and venoms. While a postdoctoral fellow at Duke, he met Prof. John W. Moore which initiated Dr. Sevcik's interest in computer modeling of living systems. While studying tetrodotoxin effects, in 1976, he provided the first evidence of the existence of sodium ion isochanels, sodium channels with different pharmacological properties in the same nerve cell. Nearly simultaneously, he participated in experiments which demonstrated that the neuroglial cell ionic channels, although voltage insensitive, have the same pharmacological receptors for tetrodotoxin, grayanotoxin, batracotoxin and veratratridine, as the neighboring neurons.

Biography Updated on 4 September 2012

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