William Carson

The Ohio State University, USA

William Carson has an M.D. degree. He took the form of a four-year fellowship at the Roswell Park Cancer Institute in Buffalo, NY, USA. The first two years of the fellowship consisted of advanced training in surgical oncology. Following this, Dr. Carson embarked on a two-year course of research as an NIH T32 Investigator at the laboratory of Dr. Michael A. Caligiuri, a medical oncologist with an interest in the effects of novel cytokines on the innate immune system. In this laboratory, Dr. Carson learned of the therapeutic potential of recombinant cytokines in malignant disease as well as the importance of drug schedule and dosing in achieving the desired antitumor response. The trials that evolved from these basic observations emphasized the use of physiologic concentrations of cytokines and employed carefully designed correlative studies to monitor the immunologic effects of these treatments. This experience led to a number of first author papers that appeared in high-impact journals (Blood, Journal Experimental Medicine, Proceedings of the National Academy of Sciences). His work on the effects of IL-15 on NK cell function led to an NIH K11 Physician-Scientist Award. Dr. Carson joined the Division of Surgical Oncology at the OSU and transferred his K11 award to the OSU in June 1997. He has initiated or facilitated the development of over 25 immunology-based clinical trials, including two national trials in melanoma. He received his K24 award in 2002, and as a result he was able to focus on translational research and associated mentorship activities. Currently, Dr. Carson holds five NCI peer-reviewed grants as PI (1 T32, 2 R21s, 1 K24, and 1 project in an Innate Immunity P01 Program project). Because of his leadership in translational immunologic research, he was named the Associate Director for Clinical Research for the OSU CCC and the Director of the OSU CCC Immunology Program.

Biography Updated on 16 August 2009

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