Eugenie S. Kleinerman

University of Texas MD Anderson Cancer Center, USA


Eugenie S. Kleinerman received a B.A. degree from the Washington University in St. Louis, USA, and an M.D. degree from the Duke University, USA. She completed a Pediatric Residency at the Children's Hospital National Medical Center in Washington, DC, and a Fellowship at the NCI. She served as a Senior Investigator at the NCI-FCRF before moving to the University of Texas MD Anderson Cancer Center where she was promoted from an Assistant Professor to a Professor. In 2001, she became the Head of the Division of Pediatrics, the first woman Division Head at the MD Anderson Cancer Center. Her research, funded by NCI for about 25 years, led to the development of an immunotherapy (L-MTP-PE) for metastatic osteosarcoma in the lungs. She conducted two phase II trials demonstrating L-MTP-PE’s effectiveness in relapsed patients. A phase III trial showed L-MTP-PE's efficacy with chemotherapy. Her research focuses on mechanisms involved in osteosarcoma metastasis to the lung. She demonstrated that tumor Fas expression and the Fas/FasL pathway are critical in the metastatic potential and that this pathway can be targeted for therapeutic benefit.

Biography Updated on 29 December 2013

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