Jeanette H W Leusen

University Medical Centre Utrecht, The Netherlands

Jeanette H W Leusen received her Ph.D. degree in 1995, on the structure and function of the human NADPH oxidase, at the Universty of Amsterdam. Since then, She worked at the University Medical Center in Utrecht, first at the Cell Biology Department and since 1998 at the Immunology Department. Her entry into the Fc receptor biology/ therapeutic antibodies field began when she was awarded a prestigious fellowship from the Netherlands Scientific Organization (NWO). In the last 5 years, Dr. Leusen's research has focussed on the signaling of Fc Receptors, both inside out (PNAS and J Biol Chem 2004, J. Immunology 2008, and Blood 2010) and outside in (Cancer Research, 2010). In parallel, Dr Leusen is actively involved in the in vivo studies of therapeutic antibodies using several mouse models. Within the immunotherapy group, a unique panel of Fc receptor knockout and transgenic animals has been developed and obtained over the past decades (e.g., Immunity, 2001; Cancer Research 2006). Supported by grants from KWF and AICR, she has generated and characterized a new transgenic mouse reconstituting FcR expression but incapable of ADCC (Cancer research, 2010). Dr Leusen is now Head of the Immunotherapy Group as an Associate Professor.

Biography Updated on 2 May 2011

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