María Sasiain

Academia Nacional de Medicina, Argentina


María Sasiain has a PhD degree in Biochemistry, is a member of Research Career of National Research Council (CONICET) and Head of Immunology of Respiratory Diseases in the Institute of Experimental Medicine (IMEX)-CONICET, National Academy of Medicine, Buenos Aires, Argentina. The research is focused at innate and adpaptive immunology of respiratory diseases focusing on the mechanisms involved in immunity to Mycobacterium tuberculosis, in host cell parasitism, and in mycobacterial pathogenesis. Short list of our main contributions to mycobacterial research. Schierloh P et al. Increased susceptibility to apoptosis of CD56dim CD16+ NK cells induces the enrichment of IFN-? producing CD56bright cells in tuberculous pleurisy. J. Immunol 175: 6852-6860, 2005. Schierloh P et al. NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells. Eur. J. Immunol. 39: 2450-58; 2009. Geffner L et al. Patients with multidrug resistant tuberculosis display impaired Th1 response and enhanced regulatory T cells levels in response to M and Ra outbreak multidrug resistant Mycobacterium tuberculosis strains. Infect. Immun. 77:5025-34, 2009. Balboa L et al. Paradoxical role of CD16+CCR2+CCR5+ monocytes in tuberculosis: efficient APC in pleural effusion but also mark disease severity in blood. J.Leucok Biol 90:69-75, 2011. Basile JI et al. Outbreaks of M.tuberculosis MDR strains induce high IL-17 T cell response in patients with MDR tuberculosis that is closely associated with high antigen load. J. Infect. Dis 204:1054-64, 2011. Yokobori N et al. Differential induction of macrophage cell death by antigens of a clustered and a non-clustered multidrug-resistant Mycobacterium tuberculosis strain from Haarlem family. FEMS Immunol Med Microbiol 66: 363–371, 2012. Balboa L et al. Impaired dendritic cell differentiation of CD16-positive monocytes in tuberculosis: role of p38 MAP kinase. Eur. J. Immunol 43(2):335-47, 2013.

Biography Updated on 28 May 2013

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