I obtained a B. Sc. degree in the Pierre and Marie Curie University (Paris, France) with a major in Biochemistry. In 1996, I completed my Ph. D. in Molecular and Cellular Biology at the Laboratory of Structural Enzymology and Biochemistry (Gif sur Yvette, France) under the supervision of Dr Moncef Ladjimi. During my Ph. D., I have characterized the structure in solution of the molecular chaperone Hsc70 and studied how its oligomerization would influence is chaperone activities. After graduation, I joined the laboratory of Dr Alfred L. Goldberg in the Department of Cell Biology at Harvard Medical School (Boston, USA). As a postdoctoral fellow, my research focused on the role of proteasome-associated ATPases in protein degradation. I have also studied the protection of yeast cells by trehalose against oxidants. Since 2002, I am a scientist staff at the Pasteur Institute (Paris, France). I have studied the proteolytic activity of the ClpP1 and ClpP2 peptidases of Mycobacterium tuberculosis and characterized an open reading frame of unknown function in the actinomycete Streptomyces. Since 2010, I have joined the Biology of Spirochetes laboratory in the department of Microbiology of the Pasteur Institute where I am studying the Ferric uptake regulators of Leptospira. My area of expertise include chaperone, stress response, protein degradation, gene expression regulation, metal uptake, spirochetes.
Biography Updated on 1 March 2012