Richard J. Staba

University of California, Los Angeles, USA


Ph.D. in Neurobiology from Department of Neurobiology, UCLA and currently an Associate Professor in Department of Neurology, David Geffen School of Medicine at UCLA. Research focuses on neuronal and anatomical mechanisms generating seizures and interictal epileptiform activity, e.g. pathological high frequency oscillations (HFOs), in human drug-resistant epilepsy and experimental models of chronic epilepsy and traumatic brain injury with emphasis on mesial temporal lobe epilepsy and posttraumatic epileptogenesis. In addition, studies on neurophysiology of mammalian limbic system, particularly hippocampus and entorhinal cortex, in relation to changes in states of vigilance such as slow wave and rapid eye movement sleep. Current techniques include electroencephalography and intracerebral electrophysiology recorded from microelectrodes that focus on local field potentials (slow waves and spindles in sleep, gamma, ripple oscillations) and single neuron analysis; extracellular microdialysis of biogenic amines; structural magnetic resonance imaging (MRI) using three dimensional surface contour mapping and gray matter thickness analysis; MRI and histological analysis of morphological alterations associated with epileptogenicity, such as hippocampal sclerosis.

Biography Updated on 13 August 2012

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