Gemma L. Holliday



Having studied Chemistry at the University of St Andrews (UK) and my PhD with John Mitchell at the University of Cambridge (UK) in Cheminformatics, I moved to the EMBL - European Bioinformatics Institute where I worked with Janet Thornton on understanding the chemistry of enzymes (using MACiE) and am now a member of the Babbitt laboratory. I am responsible for the creation and design of the MACiE Database, a unique database that focusses on the reaction mechanisms of enzymes (a project I started during my PhD and is now in its 10th year). MACiE also includes links to Metal-MACiE (a database of the metal cofactors in MACiE entries) and CoFactor (a database of organic cofactors). I continue to develop and use MACiE,and now also work on the SFLD (Structure-Function Linkage Database) at UCSF, utilising both of these resources to produce more powerful tools in understanding enzyme chemistry. I am also working on the Radical SAM superfamiliy of enzymes, trying to understand their evolution in context of the larger superfamily.

Biography Updated on 12 August 2012

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