Kenneth K. W. To

School of Pharmacy, The Chinese University of Hong Kong, Hong Kong

Kenneth K.W. To received his Ph.D. degree in medicinal and pharmaceutical chemistry from the Chinese University of Hong Kong (CUHK) and has more than 10 years of experience in cancer research. He obtained his postdoctoral training at the National Cancer Institute, NIH, where he conducted extensive studies to understand the epigenetic mechanisms contributing to overexpression of the multidrug resistance (MDR) transporter ABCG2 in resistant cancer cells. To's recent work revealed that ABCG2 overexpression is commonly caused by microRNA dysregulation and alternative polyadenylation of ABCG2 transcript, thereby leading to the resistance phenotype in cancer cell line models. In 2008, he joined the School of Pharmacy at CUHK. Since then, Professor To has devoted his effort to explore the potential use of the microRNA-mediated ABCG2 regulatory pathway as a predictive biomarker for chemosensitivity in colorectal cancer patients. He is also evaluating the use of novel drug combinations and developing new multitargeting drug candidates in an attempt to circumvent cancer drug resistance.

Biography Updated on 17 January 2012

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