Paul C. Kuo0000-0003-0904-8636
Paul C. Kuo is a Professor of surgery and Chairman, Department of Surgery, Loyola University, Chicago, IL, USA. He received his B.S. degree in medicine and M.S. degree in business administration from Johns Hopkins University, Baltimore, MD, USA. He completed his residency training in surgery at Brigham and Women's Hospital, Harvard University, and fellowship training in transplant surgery at New England Deaconess Hospital, Boston, MS, USA. Professor Kuo also holds the position of Director of Oncology Research Institute at Loyola University. Professor Kuo's research lab has worked in the OPN field for almost ten years, originally stumbling upon OPN as a negative feedback regulator of inducible nitric oxide synthase expression. The lab is currently funded via an NIH R01 to examine the mechanism underlying OPN regulation of STAT1 ubiquitination in states of sepsis and inflammation and an R21 to address the role of OPN blockade in HCC. The lab has developed an RNA aptamer targeting OPN which demonstrated its in vivo efficacy in a murine xenograft model of breast cancer. Professor Kuo has published extensively on the role of OPN in breast, colorectal, and liver cancer.
Biography Updated on 30 November 2013