Carlos Zaragoza

Fundacion Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain

Carlos Zaragoza received in 1990 his B.S. degree from the University Complutense of Madrid, Spain. In 1996, he received his Ph.D. degree from the Department of Genetics for his contribution in study of genetic mutations caused by the activation of mobile genetic elements. In 1995, he moved to the Spanish Council for Scientific Investigations, where he started to work in an emerging field of research, characterizing the controlling region of the gene, which encodes for the inducible nitric oxide synthase to address the effect of nitric oxide on the inflammatory response. In 1996, as a Postdoctoral Fellow at the Johns Hopkins School of Medicine, he studied the relevance of nitric oxide in the in the host defense against viral pathogens in cardiovascular pathology, in particular during Coxsackievirus-mediated myocarditis. Back in Spain, he joined the Spanish Council for Scientific Investigations, where he is now running the Laboratory of Vascular Wall Remodeling and Cardiovascular Disease, Department of Atherothrombosis and Cardiovascular Imaging. His research is focused in finding the molecular determinants triggered by the actions of vasoactive factors and proteolytic enzymes during the early steps of vascular wall remodeling, a fundamental process which plays a key role in the development and progression of atherosclerosis, aneurysm, myocardial infarction, and arterial hypertension, four of the most prevalent diseases worldwide. By using animal models of cardiovascular disease, the ultimate goal is to translate the results of the research into clinical tools for diagnosis and treatment.

Biography Updated on 13 April 2011

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