Metal-Based Drugs
Volume 3 (1996), Issue 5, Pages 227-232

1,3,4-Thiadiazole Derivatives. Part 91. Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole

1Research Center for Macromolecular Materials and Membranes, Spl. Independentei 206, Bucharest 79611, Romania
2University of Bucharest, Department of Inorganic Chemistry, Str. Dumbrava Rosie 23, Bucharest, Romania
3Polytechnic University of Bucharest, Department of Inorganic Chemistry, Polizu 1, Bucharest 79611, Romania
4Università degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, Florence I-50121, Italy

Received 13 September 1996; Accepted 17 September 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metal complexes of the title ligand (L) containing Co(II), Ni(II) and Cu(II) were prepared and characterized by elemental analysis, IR, electronic spectroscopy and conductimetry. The new derivatives, possessing the following formulae, CuL2(OH)2, NiL2Cl2, and [Co2LCl4]n showed in vitro antifungal activity against Aspergillus and Candida spp.