Developing Carrier Complexes for “Caged NO”: R<small.letters>u</small.letters>C<small.letters>l</small.letters>3(NO)(H2O)2 Complexes of Dipyridylamine, (<small.letters>dpa</small.letters>H), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (<small.letters>tpada</small.letters>), and (2-Pyridylmethyl) Iminodiacetate, (<small.letters>pida</small.letters>2-)

Slocik, Joseph M.; Kortes, Richard A.; Shepherd, Rex E.

doi:https://doi.org/10.1155/MBD.2000.67

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Volume 7 | Article ID 641519 | https://doi.org/10.1155/MBD.2000.67

Developing Carrier Complexes for “Caged NO”: RuCl₃(NO)(H₂O)₂ Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida^2-)

Joseph M. Slocik,¹Richard A. Kortes,¹and Rex E. Shepherd¹

Received21 Feb 2000

Abstract

Delivery agents which can carry the {Ru(NO)}6 chromophore (“caged NO”) are desired for vasodilation and for photodynamic therapy of tumors. Toward these goals, complexes derived from [RuCl3(NO)(H2O)2]= (1) have been prepared using dipyridylamine (dpaH) as mono and bis adducts, [Ru(NO)Cl3(dpaH)] = (2) and [Ru(NO)Cl(dpaH)2]Cl2 = (3). The dpaH ligands coordinate cis to the Ru(NO) axis.The mono derivative is a model for a potential DNA groove-spanning binuclear complex {[Ru(NO)Cl3]2(tpada)} = (4) which has two DNA-coordinating RuII centers, photo-labile {Ru(NO)}6 sites, and a groove-spanning tether moiety.The binuclear assembly is prepared from the tethered dipyridylamine ligand N,N,N',N'-tetrakis(2-pyridylmethyl)adipamide (tpada) which has recently been shown to provide a binuclear carrier complex suited to transporting RuII and PdII agents. A related complex, [Ru(NO)Cl(pida)] = (5) with the {Ru(NO)}6 moiety bound to (2-pyridylmethyl) iminodiacetate (pida2-) is also characterized as a potential “caged NO” carrier. Structural information concerning the placement of the pyridyl donor groups relative to the {Ru(NO)}6 unit has been obtained from H1 and C13 NMR and infrared methods, noting that a pyridyl donor trans to NO+ causes “trans strengthening” of this ligand for [Ru(NO)Cl(pida)], whereas placement of pyridyl groups cis to NO+ causes a weakening of the N-O bond and a lower NO stretching frequency in the dpa-based complexes.

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Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Metal-Based Drugs

Developing Carrier Complexes for “Caged NO”: RuCl3(NO)(H2O)2 Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida2-)

Abstract

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Developing Carrier Complexes for “Caged NO”: RuCl₃(NO)(H₂O)₂ Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida^2-)