Pancreatic Cancer Suppression by Natural Polyphenols

Cui, Guoliang; Zhang, Yuebo; Liu, Cindy; Skinner, Sheri; Qin, Ying

doi:https://doi.org/10.3814/2008/540872

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Research Article | Open Access

Volume 2008 | Article ID 540872 | https://doi.org/10.3814/2008/540872

Pancreatic Cancer Suppression by Natural Polyphenols

Guoliang Cui,¹Yuebo Zhang,¹Cindy Liu,²Sheri Skinner,²and Ying Qin^1,2

Received10 Jun 2008

Accepted01 Aug 2008

Published26 Aug 2008

Abstract

Resveratrol and quercetin are polyphenols abundant in frequently consumed fruits, vegetables, and red wine. They have many biological activities, including antitumor, anti-inflammation, and antioxidation effects. This study evaluates the chemopreventive potential of resveratrol and quercetin against pancreatic cancer and investigates some of the underlying mechanisms. We report that resveratrol and quercetin suppress pancreatic tumor growth and that resveratrol extends life expectancy in a tumor bearing mouse model. Further, these two polyphenols inhibit growth of pancreatic cancer cell line, Panc02, in vitro. Results suggest that mechanisms may include induction of expression of caspase 3/8, causing DNA fragmentation, and arresting cells in G1 phase of the cell cycle. Cell invasion data reveals that both resveratrol and quercetin are able to decrease tumor cell invasion through an endothelial barrier. These data suggest that resveratrol and quercetin may be beneficial in pancreatic cancer treatment and metastasis prevention.

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Copyright

Copyright © 2008 Guoliang Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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