Clinical Study
Pharmacokinetics of Oral Taurine in Healthy Volunteers
Table 2
Pharmacokinetic parameters of taurine after oral administration of 4 g (32 mmoL) taurine capsules.
| | Subjects | (mg/L) | (hr) | (mghr/L) | (hr-1) | T1/2 (hr) | V (L) | Cl/F (L/hr) |
| | 1 | 69.7 | 1 | 127.7 | 0.8 | 0.8 | 37.8 | 31.2 | | 2 | 66.7 | 1 | 198.0 | 0.5 | 1.4 | 40.7 | 19.5 | | 3 | 112.6 | 2 | 281.4 | 0.6 | 1.1 | 22.1 | 14.0 | | 4 | 100.4 | 1 | 235.0 | 0.6 | 1.1 | 26.8 | 16.9 | | 5 | 86.1 | 2 | 232.0 | 0.5 | 1.4 | 32.5 | 16.6 | | 6 | 99.5 | 2.5 | 284.5 | 0.7 | 1 | 19.8 | 14.0 | | 7 | 59.0 | 1.5 | 116.0 | 1.0 | 0.7 | 34.8 | 34.4 | | 8 | 94.8 | 1.0 | 175.9 | 0.9 | 0.8 | 25.1 | 22.2 |
| | Mean | 86.1 | 1.5 | 206.3 | 0.7 | 1.0 | 30.0 | 21.1 | | SD | 19.0 | 0.6 | 63.9 | 0.2 | 0.3 | 7.6 | 7.8 | | Range | 59.0–112.6 | 1–2.5 | 116.0–284.5 | 0.5–1.0 | 0.7–1.4 | 19.8–40.7 | 14.0–34.4 |
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