A Novel Algorithm for the Assessment of Blood-Brain Barrier Permeability Suggests That Brain Topical Application of Endothelin-1 Does Not Cause Early Opening of the Barrier in Rats
Figure 5
SDs in presence and absence of ET-1. (a) shows a typical SD in the cortex exposed to ET-1, while (b) demonstrates a typical SD in naïve cortex. Note the difference in duration and shape of the SDs. It has been suggested that ET-1 induces conditions of an ischemic penumbra. In the ischemic penumbra, SDs are typically prolonged.
