Post-translational modifications for p53, a tumor-suppressor protein, responsible for maintaining the genomic stability in a cell. The figure illustrates various posttranslational modifications that are frequently observed in p53 with varied functional implications in normal and/or diseased condition. The amino acid residues that most often undergo the respective modifications in a given context have been highlighted. For details of posttranslational alterations in p53 refer to [113–127].