Research Article
Insights into DNA Platination within Unusual Structural Settings
Table 2
15N/1H chemical shifts of 2D [1H, 15N] HSQC NMR cross-peaks for the reactions of oligonucleotides with [Pt(15NH3)2I2].
| Sample | Code | Complex | Peak | δ(15N/1H) | 15 N trans to |
| “GpG” decamer | V | cis-[Pt(15NH3)2I{d(V-G6-N7)}]+ | 15 | −47.43/4.39 | I | | | | 16 | −75.56/4.02 | N | | | cis-[Pt(15NH3)2{d(V-G5-N7,G6-N7)}]2+ | 17 | −67.49/4.59 | N | | | | 18 | −68.68/4.52 | N | “GsG” duplex | Vs | R or S cis-[Pt(15NH3)2I{d(Vs-S)}]+ | 19 | −46.76/4.13 | S | | | | 21 † | −54.35/3.92 | I | | | S or R cis-[Pt(15NH3)2I{d(Vs-S)}]+ | 20 | −46.30/4.10 | S | | | | 21 † | −54.35/3.92 | I | “GpA” duplex | VI | cis-[Pt(15NH3)2I{d(VI-G3-N7)}]+ | 22 | −46.57/4.35 | I | | | | 23 | −75.02/4.13 | N | | | cis-[Pt(15NH3)2I{d(VI-G3-N7)}]+ | 22 | −46.57/4.35 | I | | | | 24 | −75.87/4.06 | N | | | cis-[Pt(15NH3)2{d(VI-G3-N7, G3-N7)}]2+ | 25 | −66.99/4.60 | N | | | | 26 | −67.71/4.46 | N | “GsA” duplex | VIs | R or S cis-[Pt(15NH3)2S,{d(VIs-G5-N7)}]2+ | 27 | −44.74/4.23 | S | | | | 29 † | −66.99/4.16 | N | | | S or R cis-[Pt(15NH3)2S,{d(VIs-G5-N7)}]2+ | 28 | −46.26/4.22 | S | | | | 29 † | -66.99/4.16 | N | | | cis-[Pt(15NH3)2I{d(VIs-S)}]+ | 30 | −47.64/4.06 | S | | | | 31 | −54.65/4.04 | I | “GpT” octamer | VII | cis-[Pt(15NH3)2-N,N]2+ | — | −66.57/4.51 | N | | | | — | −67.01/4.41 | N | “GsT” octamer | VIIs | cis-{Pt(15NH3)2-N,N}2+ | — | −66.76/4.55 | N | | | | — | −67.12/4.42 | N | | | cis-{Pt(15NH3)2-I,S}+ major | | −54.49/3.94 | I | | | | | −45.87/4.07 | S | | | cis-{Pt(15NH3)2-I,S}+ minor | | −55.26/3.88 | I | | | | | −47.78/4.09 | S | | | R or S cis-[Pt(15NH3)2{S,d(VIIs-T5-N3)}]2+ | — | −46.77/4.44 | S | | | | — | −67.05/4.19 | N | | | S or R cis-[Pt(15NH3)2{S,d(VIIs-T5-N3)}]2+ | — | −46.34/4.35 | S | | | | — | −66.12/4.18 | N |
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†Overlapping peaks.
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