Journal of Amino Acids
Volume 2011 (2011), Article ID 352538, 11 pages
http://dx.doi.org/10.4061/2011/352538
Review Article

The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis

1Department of Chemistry, University of Toledo, Toledo, OH 43606, USA
2Structural Biology Lab, Cold Spring Harbor Labs, Cold Spring Harbor, NY 11724, USA
3Rocky Mountain Labs, National Institutes of Health, Hamilton, MT 59840, USA
4Department of Pharmacology, Yale University, New Haven, CT 06520, USA

Received 2 October 2010; Accepted 7 November 2010

Academic Editor: Shandar Ahmad

Copyright © 2011 Ronald E. Viola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [11 citations]

The following is the list of published articles that have cited the current article.

  • Rajender Kumar, and Prabha Garg, “Molecular Modeling and Active Site Binding Mode Characterization of Aspartate beta-Semialdehyde Dehydrogenase Family,” Molecular Informatics, vol. 32, no. 4, pp. 377–383, 2013. View at Publisher · View at Google Scholar
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  • Bharani Thangavelu, Alexander G. Pavlovsky, and Ronald Viola, “ Structure of homoserine O -acetyltransferase from Staphylococcus aureus : the first Gram-positive ortholog structure ,” Acta Crystallographica Section F Structural Biology Communications, vol. 70, no. 10, pp. 1340–1345, 2014. View at Publisher · View at Google Scholar
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  • Bharani Thangavelu, Pravin Bhansali, and Ronald E. Viola, “Elaboration of a Fragment Library Hit Produces Potent and Selective Aspartate semialdehyde Dehydrogenase Inhibitors,” Bioorganic & Medicinal Chemistry, 2015. View at Publisher · View at Google Scholar
  • Rajender Kumar, Prabha Garg, and P.V. Bharatam, “ Pharmacoinformatics analysis to identify inhibitors of Mtb -ASADH ,” Journal of Biomolecular Structure and Dynamics, pp. 1–14, 2015. View at Publisher · View at Google Scholar
  • Gopal Dahal, and Ronald E. Viola, “ Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans ,” Acta Crystallographica Section F Structural Biology Communications, vol. 71, no. 11, pp. 1365–1371, 2015. View at Publisher · View at Google Scholar
  • Yu-Hsuan Ho, Pramod Shah, Yi-Wen Chen, and Chien-Sheng Chen, “ Systematic Analysis of Intracellular-targeting Antimicrobial Peptides, Bactenecin 7, Hybrid of Pleurocidin and Dermaseptin, Proline–Arginine-rich Peptide, and Lactoferricin B, by Using Escherichia coli Proteome Microarrays ,” Molecular & Cellular Proteomics, vol. 15, no. 6, pp. 1837–1847, 2016. View at Publisher · View at Google Scholar
  • Qinqin Li, Zhixia Mu, Rong Zhao, Gopal Dahal, Ronald E. Viola, Tao Liu, Qi Jin, and Sheng Cui, “Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species,” Scientific Reports, vol. 6, pp. 21067, 2016. View at Publisher · View at Google Scholar
  • Thomas Walther, Christopher M. Topham, Romain Irague, Cl?ment Auriol, Audrey Baylac, H?l?ne Cordier, Cl?mentine Dressaire, Luce Lozano-Huguet, Nathalie Tarrat, Nelly Martineau, Marion Stodel, Yannick Malbert, Marc Maestracci, Robert Huet, Isabelle Andr?, Magali Remaud-Sim?on, and Jean Marie Fran?ois, “Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid,” Nature Communications, vol. 8, pp. 15828, 2017. View at Publisher · View at Google Scholar
  • Gopal P. Dahal, and Ronald E. Viola, “ Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus ,” Acta Crystallographica Section F Structural Biology Communications, vol. 73, no. 1, pp. 36–44, 2017. View at Publisher · View at Google Scholar