SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques
Figure 7
Neuropathological staining of compounds 12 (a)–(d), 13 (e)–(h), 14 (i)–(l), and 15 (m)–(p) on 5 μm AD brain sections from the temporal cortex. (a) Aβ plaques (a), (e), (i), and (m) are clearly stained with 12, 13, 14, and 15 (×40 magnification). Clear staining of neuritic plaques (b), (f), (j), and (n) and cerebrovascular amyloid (c), (g), (k), and (o) was also obtained. Many NFTs (d), (h), (l), and (p) are intensely stained with 12, 13, 14, and 15 (×40 magnification).