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| Author | Questionnaire(s) used | Mean score | Severity assessment | Overall effect on gender | Symptoms/feelings | Work | Daily activities/functioning | Social/interpersonal activities | Others |
|
| Hutchings et al. [29] | DLQI, part of SF-36 | DLQI 6.6; SF-36 NA | NA | No difference | Most affected domain with higher effect on female | Affected but not prevented with higher effect on males | NA | Least affected domain | |
|
| Holness [30] | Modified DLQI, open-ended questions | DLQI NA | NA | NA | 61% complained of itchiness/pain, 36% felt embarrassed | 20% could not work and 43% had interference with work | 32% had sleep disturbance, 23% had interference with housework/shopping | 20% were affected | Those with hand involvement reported a worse QoL. |
|
| Kadyk et al. [31] | Skindex-16, additional questions on occupational impact | Skindex-16 individual scale ranges from 13.3–31.0 | NA | NA | NA | Significantly more affected compared to those with nonoccupational ACD | Slightly more impaired than those with nonoccupational ACD | Concerned that interaction with coworkers may be difficult | |
|
| Lewis et al. [32] | DLQI | Before diagnosis 17.9; after diagnosis 10.9 | NA | NA | NA | 39% reported severe impact on work | NA | 44% had issues with interpersonal relationships | |
|
| Wallenhammar et al. [33] | DLQI, SF-36 | DLQI 7.4; SF-36 PCS 45.3; MCS 46.4 | NA | No difference on DLQI; female had more impaired QoL on SF-36 | Very large effect | Most affected domain in DLQI, significantly reduced role-physical domain in SF-36 | 23% females and 18% males reported interference with daily activities | Personal relationship was the least effected | |
|
| Meding et al. [34] | Self-developed questionnaires | NA | NA | NA | 52% had symptoms > half of the time; females more affected, 80% reported itching to their hand eczema | 82% changed work situation, 44% changed job | NA | 88% reported effect on psychosocial and had to give up on their hobbies | 28% had total recovery |
|
| Lazarov et al. [35] | DLQI, self-developed questionnaires | DLQI NA | NII-rated | NA | 45.7% feeling shame and rejected | 52.9% changed job | 45.7% reported interference | 18.6% had limitations in interpersonal relationship | 11.4% had persistent dermatitis |
|
| Cvetkovski et al. [36] | DLQI, BDI-II | DLQI 5.5; BDI-II 7.1 | DNBII-rated | No difference | Most affected domain, 9% reported moderate-to-severe depression at baseline and at followup | Most affected domain at baseline | NA | NA | Strong association between mild-to-moderate OHE and severe OHE and low QoL at baseline |
|
| Soder et al. [37] | SF-36, Skindex-29 | SF-36 individual scale ranges from 53.9–81.4; Skindex-29 individual score range 23.0–56.9 | Physician-assessed | Females more affected in most subscales of SF-36 | Most affected domain with 12.7% reported itchiness on entire skin surface & 37.7% on hands | 31.1% had <8 weeks of sick leave; 48.6% were absent from work. 23.1% from telephone survey changed or gave up their profession | Least affected domain in Skindex | NA | No significant correlation between severity of skin and QoL. 65% from telephone survey had improved skin |
|
| Matterne et al. [38] | SF-36, Skindex-29 | SF-36 individual scale ranges from 54.2–89.6; Skindex-29 raw score NA | Yes | No difference on SF-36, females more affected on Skindex-29 | Females reported more emotional impairment, more impaired social functioning and mental health | NA | Less impaired physical functioning compared to general population | NA | More severe skin is associated with perceived pain |
|
|
Lau et al. [39] | DLQI, SF-36 | DLQI 4.5; SF-36 PCS 52; MCS 51 | Physician-rated, patient-rated, ODDI | No difference | Most affected domain in DLQI, lower mental health scores | Very large effect | Moderately affected as measured by DLQI, no effect in SF-36 domains | No effect on social functioning | Significant correlation between severity of skin and QoL. 21% had complete clearance; 18% progressed to PPOD |
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