Research Article

Development of an Oral Form of Azacytidine: 𝟐 𝟑 𝟓 Triacetyl-5-Azacytidine

Table 1

Stability of TAC and its metabolites at various pH.

SampleTAC (%)DAC (%)MAC (%)ACT (%)

Control100

pH 1—1 hr99100
pH 1—3 hr742240
pH 1—6 hr3841210
pH 1—29 hr1223146

pH 3—1 hr97300
pH 3—3 hr96400
pH 3—6 hr92620
pH 3—29 hr93421

pH 5—1 hr98200
pH 5—3 hr94600
pH 5—6 hr98200
pH 5—29 hr94411

pH 7.4—1 hr96400
pH 7.4—3 hr91720
pH 7.4—6 hr851230
pH 7.4—29 hr6917131

TAC: tri-acetyl-azacitidine; DAC: di-acetyl-azacitidine; MAC: mono-acetyl-azacitidine; ACT: azacitidine.