Organic Chemistry International

Research Article

A Solvent-Free Protocol for the Green Synthesis of 5-Arylidene-2,4-thiazolidinediones Using Ethylenediamine Diacetate as Catalyst

Table 3

EDDA catalyzed synthesis of 5-arylidene-2,4-thiazolidinedionesa.

Entry		Aldehyde ProductTime (min) Yieldb (%)M.p. (°C)
FoundLiterature
1194784.tab.003a194784.tab.003b391241-242241-242 [23]
2194784.tab.003c194784.tab.003d388230–232225-226 [23]
3194784.tab.003e194784.tab.003f491218–220218-219 [23]
4194784.tab.003g194784.tab.003h789224-225220-221 [19]
5194784.tab.003i194784.tab.003j784192–194187–190 [5]
6194784.tab.003k194784.tab.003l879281-282281 [17]
7194784.tab.003m194784.tab.003n4070187–189185–190 [19]
8194784.tab.003o194784.tab.003p2291195–197194 [17]
9194784.tab.003q194784.tab.003r882226–228223-224 [19]
10194784.tab.003s194784.tab.003t65 (20c)79 (90c)213–215215 [17]
11194784.tab.003u194784.tab.003v50 (15c)74 (85c)260–262261–263 [9]
12194784.tab.003w194784.tab.003x7589228–230225-226 [19]
13194784.tab.003y194784.tab.003z1585309-310310–312 [23]
14194784.tab.003aa194784.tab.003bb3080219–221218–220 [19]
15194784.tab.003cc194784.tab.003dd281231–233230–233 [19]
aReaction condition: aldehyde (10 mmol), 2,4-thiazolidinedione (10 mmol), EDDA (0.5 mmol) at 80°C under solvent-free conditions.
bIsolated yield.
cReactions were carried out at 90°C.