International Journal of Molecular Imaging

Research Article

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group

Table 4

mRNA expression for a panel of cation transporters according to tumor MIBG avidity in 27 patients with neuroblastoma and centrally reviewed MIBG scans.a
 MIBG Avid
( )		MIBG Nonavid
( )
Median OCT1 mRNA0.17% 0.11%
(range)(0.04–0.48%)(0.03–0.90%)
Median OCT3 mRNA0.60%1.3%
(range)(0.04–127%)(0–6.47%)
Median MATE1 mRNA5.9%8.2%
(range)(0.39–57%)(0.43–102%)
Median VMAT1 mRNA89%13%
(range)(0.68–348%)(0.43–1590%)
Median VMAT2 mRNA175%27%
(range)(2.7–2661%)(0.98–1253%)
aTransporter expression is expressed as a percent of PGK1 expression. OCT2 mRNA expression was observed in only two tumors.