International Journal of Molecular Imaging

Review Article

PET Imaging in Recurrent Medullary Thyroid Carcinoma

Table 3

Technical aspects of the studies which used FDOPA-PET or PET/CT for detecting recurrent medullary thyroid carcinoma.
AuthorsStudy designDeviceInjected activityTime between tracer injection and image acquisition (min)PET acquisition protocolImage analysisReference standardSensitivity of FDOPA-PET or PET/CT*Specificity of FDOPA-PET or PET/CT*
Treglia et al. [5]Retrospective multicenterPET/CT4 MBq/kg60Static acquisition (3 min per bed position)no carbidopa premedicationQualitativeHistology and/or clinical/imaging followup72%NC
Kauhanen et al. [6]Prospective multicenterPET/CT243 MBq60Static acquisition (3 min per bed position)carbidopa premedicationQualitative and semiquantitativeHistology and/or clinical/imaging followup58%NC
Luster et al. [11]Retrospective single centerPET/CT298 MBq60Static acquisition (4 min per bed position)carbidopa premedicationQualitative and semiquantitativeHistology and/or clinical/imaging followup74%100%
Marzola et al. [13]MulticenterPET/CT2.2 MBq/kg60Static acquisition (3 min per bed position)no carbidopa premedicationQualitative and semiquantitativeHistology83%NC
Beheshti et al. [16]Prospective single centerPET/CT 4 MBq/Kg30Static acquisition (4 min per bed position)no carbidopa premedicationQualitative and semiquantitativeHistology and/or clinical/imaging followup81%NC
Koopmans et al. [18]Prospective single centerPET180 MBq60Static acquisition; (5 min per bed position)carbidopa premedicationQualitativeHistology and/or clinical/imaging followup62%NC
Beuthien-Baumann et al. [23]Retrospective single centerPET4.8 MBq/Kg45Static acquisition carbidopa premedicationQualitativeHistology and/or clinical/imaging followup47%NC
Hoegerle et al. [30]Prospective single centerPET220 MBq90Static acquisition no carbidopa premedicationQualitativeHistology and/or clinical/imaging followup60%NC
NC: not calculated; *sensitivity and specificity are reported on a per patient-based analysis.