Volume 2012 (2012), Article ID 346084, 15 pages
Review Article

Diagnostic Workup of Small B Cell Lymphomas: A Laboratory Perspective

1Department of Pathology, Professional Pathology Services, 1 Science Court, Suite 200, Columbia, SC 29203, USA
2Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University Health Pathology Laboratory, 350 W. 11th Street IUHPL 5044, Indianapolis, IN 46202, USA

Received 11 August 2012; Accepted 25 September 2012

Academic Editor: Jan Delabie

Copyright © 2012 Kathryn Rizzo and Mehdi Nassiri. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Small B cell lymphoma is a morphological designation to a group of B cell lymphomas which are composed of a clonal population of small lymphoid cells. The subtypes of this category have diagnostically distinct characteristics and different clinical behaviors and treatment. Correct diagnosis and classification of these subsets depend on the integration of morphologic, immunophenotypic, and molecular genetic features. In this paper, differential diagnosis of this category of tumors and a practical approach based on biomarker evaluation are discussed.