Novel Drugs Targeting the Epidermal Growth Factor Receptor and Its Downstream Pathways in the Treatment of Colorectal Cancer: A Systematic Review

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Study</td><td align="center">Status</td><td align="left">Results</td><td align="center">NCT identifier</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">IRESSA + Xeloda after failure of first-line chemotherapy</td><td align="center">Completed</td><td align="left">Pending</td><td align="center">NCT 00242788</td></tr><tr><td align="left">Gefitinib and combination chemotherapy in advanced or recurrent CRC</td><td align="center">Completed</td><td align="left">Pending</td><td align="center">NCT 00052585</td></tr><tr><td align="left">Oxaliplatin <svg height="9.5625" id="M3" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 10.1 9.5625" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,9.125)"><path d="M535 290h-212v-206h-58v206h-213v50h213v193h58v-193h212v-50zM535 -22h-483v50h483v-50z" id="xB1"></path></g>
</svg> gefitinib in metastatic or locally recurrent CRC</td><td align="center">Completed</td><td align="left">Gefitinib and oxaliplatin combination is ineffective in advanced CRC </td><td align="center">NCT 00026299</td></tr><tr><td align="left">Gefitinib in treating patients with mCRC as a single agent</td><td align="center">Completed</td><td align="left">Gefitinib as a single agent is ineffective in advanced CRC </td><td align="center">NCT 00025350</td></tr><tr><td align="left">ZD 1839 in treating patients with advanced CRC that has not responded to chemotherapy</td><td align="center">Completed</td><td align="left">Pending</td><td align="center">NCT 00030524</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Phase 2 clinical trials of Gefitinib in colorectal cancer.

Chemotherapy Research and Practice

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Table 3

Table 3: Novel Drugs Targeting the Epidermal Growth Factor Receptor and Its Downstream Pathways in the Treatment of Colorectal Cancer: A Systematic Review 

Table 3 | Novel Drugs Targeting the Epidermal Growth Factor Receptor and Its Downstream Pathways in the Treatment of Colorectal Cancer: A Systematic Review 