Organic Chemistry International

Research Article

[Retracted] One-Pot Synthesis of Pyrrolidine-2-ones from Erythruronolactone and Amine

Table 1

Result of the preparation of protected polyhydroxylated pyrrolidinone iminosugar (7).
Productsa RYields7a-p/7a′-p′
(5a′, 5a) Pyridin-2yl8740/60
(5b′, 5b) 2-Methylpyridin-2-yl7745/55
(5c′, 5c) 4-Methylpyridin-2-yl5633/67
(5d′, 5d) 2-Ethen-2-yl7736/63
(5e′, 5e)2,2-Diethoxyeth-2-yl5550/50
(5f′, 5f)2,2-Dimethoxymeth-2-yl5645/55
(5g′, 5g)2-Ethyn-2-yl7753/47
(5h′, 5h)Ethyl6050/50
(5i′,5i)Propyl5067/33
(5j′, 5j)Butyl6650/50
(5k′, 5k)Pentyl5050/50
(5l′, 5l)Hexyl5050/50
(5m′, 5m)Heptyl6567/33
(5n′, 5n)Octyl5050/50
(5o′, 5o)Ph7221/79
(5p′, 5p) 4-Methylmorpholin-2-yl6022/78
aMixture of epimers.