Figure 2: Th1/Th2 cytokine production from CD4+ T cells isolated from sublingually treated mice with allergic rhinitis. Culture supernatants of CD4+ T cells isolated from spleen of mice with allergic rhinitis were assessed for Th1 and Th2 cytokine production levels by ELISA. Representative results from three independent experiments containing three to five mice in each group are shown. Significance was evaluated by an unpaired t-test. .