Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition

Suramwar, Nikhil V.; Thakare, Sanjay R.; Khaty, Niraj T.

doi:https://doi.org/10.1155/2012/515092

Organic Chemistry International

On this page

Abstract Introduction Discussion Conclusion Supplementary Materials References Copyright Related Articles

Research Article | Open Access

Volume 2012 | Article ID 515092 | https://doi.org/10.1155/2012/515092

Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition

Nikhil V. Suramwar,¹Sanjay R. Thakare,²and Niraj T. Khaty¹

Academic Editor: Robert Batey

Received13 Jun 2012

Accepted14 Aug 2012

Published04 Nov 2012

Abstract

A simple and efficient method for N-arylation of 1,2,4-triazole at room temperature was described by the use of predominant (111) facet CuO nanoparticles as a catalyst in ligand-free condition. The catalyst was recyclable, and a variety of substrates give N-arylation product in high yield with short period of reaction time. The wide scope of this catalyst led us to investigate transformations involving less-reactive nitrogen nucleophiles, such as imidazole and pyrazoles. We were pleased to find that various derivatives of azoles were effectively coupled with aryl iodide to afford the desired N-arylated product in excellent yield.

1. Introduction

N-Aryl derivatives of azoles are very important organic compounds for organic synthesis because of their wide application in biology and attracted more attention as hole transport molecules for organic light-emitting diodes (LEDs) [1–3].N-Arylation of azole was carried out by metal-mediated reactions such as the Ullmann coupling [1, 2, 4], aromatic nucleophilic substitution [3, 5], and Pd or Cu catalyzed arylation [6]. However, the employment of chelating ligand, stoichiometric amount of Cr(CO)₃, and harsh reaction conditions diminished the applicability of these methods, especially for large-scale production. The transition-metal-catalyzed N-arylation of azoles with aryl halides is one of the most efficient and powerful methods for the synthesis of N-aryl derivatives [7, 8]. However, current methods have some potential limitations because these transformations often use expensive transition-metal catalyst as palladium [9], rhodium [10], nickel [11], and cobalt [12] complexes. Thus, screening out inexpensive and environmentally benign metal catalysts for the N-arylation of azoles still remains a great challenge [13]. Inexpensive copper catalysts bearing various ligands provided a highly economical and efficient method for N-arylation of nitrogen-containing heterocycles with aryl halides. The ligands employed in the Cu-catalyzed reactions included beta-diketones [14], 1,2-diamines [15], phenanthrolines [16], bipyridines [17] α-amino acids [18], phosphines [19], and others [20]. The chelating ligands play an important role in controlling the concentration of active catalytic species, but they might contaminate the final products [21]. Ligand-free catalysts could be a good alternative to avoid the inconvenience of ligand removal from reaction mixtures. In the past years, CuI [22] and Cu₂O [23] have been successfully employed as catalysts for this cross-coupling reaction in the absence of organic ligands. However, these catalytic systems often required excess substrates or high catalyst loadings [24]. It was reported that simple inorganic copper (II) salts catalyzed such coupling reactions without extra ligands were of limited scope [25].

The use of CuO nanoparticle for cross-coupling reaction was first reported by Rout et al. [26]. CuO nanomaterials containing high surface area and reactive morphologies have been studied as effective catalysts for organic synthesis [27, 28]. CuO nanomaterials were of considerable interest due to role in catalysis, in metallurgy, and in high-temperature superconductors [29, 30]. These nanoparticles were found to be effective catalysts for CO and NO oxidation as well as oxidation of volatile organic chemicals such as methanol [31, 32]. Recently, Kantam et al. reported the asymmetric hydrosilylation of prochiral ketones, asymmetric direct aldol reaction, and N-arylation of heterocycles using nanocrystalline CuO [33, 34].

The (111) plane of CuO nanoparticles contains more active sites with higher density as compared to bulk CuO and therefore these sites actively participated in the catalysis reactions. Previously we shown an excellent catalytic activity of these predominant (111) facet nanoparticles in N-arylation of indoles [35], herein we further extended our study in case of N-arylation of azoles and reported our progress in the N-arylation of azoles with optimum conditions. It was found that, the catalytic activity of these predominant (111) facet CuO nanoparticles was very high as N-arylation of 1,2,4-triazole was carried out even at room temperature with lesser reaction time and excellent yield. The main aim of our study is to give simple and efficient method for N-arylation of azoles by the use of highly active predominant (111) faceted CuO nanoparticles as a heterogeneous catalyst in a ligand free condition.

2. Result and Discussion

The CuO nanoparticles with predominant (111) plane were fabricated by thermal-assisted green strategy at reflux temperature within short period of time in our laboratory as reported [35].

2.1. Reactions of 1,2,4-Triazole with Aryl Iodide

Recently, there was a report of Cu catalyzed N-arylation of azoles with aryl halide in presence of ligand but the longer reaction time and difficulty in separation of ligand limits the method [36], whereas in our method, we can easily separate CuO nanocatalyst and recycled it for at least five times without much loss in yield of the product.

Initially, the reaction of N-arylation of 1,2,4-triazole with aryl iodides was investigated (Scheme 1).

The reaction with iodobenzene occurred at room temperature to give 1-phenyl-1H-1,2,4-triazole in good yield (84%), whereas 4-nitro-1-iodobenzene shows greater reactivity towards 1,2,4-triazole than iodobenzene with yield around (91%). Under similar condition, electron-rich 4-iodoanisole and satirically hindered 2-iodotoluene show less reactivity towards 1,2,4-triazole (Table 1, Entry 5 and 6). We carried reactions at different temperatures in order to study the effect of temperature on yield of product but there was not much considerable increase in the yield of product with increase in temperature.

N-arylation of 1,2,4-triazole was effective under air, Iodobenzene exhibited greater reactivity compared to bromobenzene. Under these conditions, chlorobenzene show less reactivity as compared to bromobenzene and Iodobenzene. The order of reactivity was iodobenzene > bromobenzene > chlorobenzene (Table 1, entries 2, 3, and 4). There was no reaction possible in the absence of CuO nanoparticles.

To our best knowledge, this is the first report of room temperature N-Arylation of 1,2,4-triazole. The reactions were clean and no other impurity due to C-arylation or biaryl was obtained.

Reaction of iodobenzene with triazole was examined with various kinds of bases. N-Arylation preceded using carbonates and yield increased in order to increase basicity. However, use of Cs₂CO₃ gave no substantial amount of the product, nor did t-BuONa.

In our catalytic system, K₂CO₃ and Rb₂CO₃ worked very well. Employment of the stronger bases might deactivate the CuO nanocatalyst. Although employing 0.5 equivalent of a base gave an acceptable yield, the reaction was accelerated using 1 equivalent of the base. N-Arylation of imidazole and pyrazole proceeded similarly. As described above, K₂CO₃ and Rb₂CO₃ promoted good activity in this reaction and the use of K₂CO₃ was more preferable practically (Table 2, entry 5 and 10). Reactions of triazole with iodobenzene was carried out in toluene at room temperature for 12 h to afford the desired product in 65% yield and, with acetonitrile, methanol, and chloroform, the conversion was less as compared to toluene (Table 2). Therefore, we examined the synthesis of N-arylation of triazole in the presence of 5 mol% of CuO nanocatalyst and 1 equivalent of K₂CO₃ with DMF as a solvent.

2.2. N-Arylation of Imidazole and Pyrazole

We extended our study in case of azoles such as imidazole and pyrazole (Table 3). Initially, the reaction was carried out at room temperature but yield of product was very less. Increased in temperature increases the percentage yield and in 3 h of reflux, we get N-arylated product with excellent yield up to 97% (Scheme 2). This might because of less reactive nature of imidazole and pyrazole which makes abstraction of hydrogen from nucleophile difficult at room temperature and N-arylation reaction occurred at refluxed temperature.

All reactions were monitored by Co-TLC and the final product characterized by LCMS, ¹H NMR, and ¹³C NMR.

2.3. Comparison of Catalytic Activity

We compared the catalytic activity of these predominant (111) facet CuO nanoparticles with commercially available CuO nanoparticles and bulk CuO powder (purchased from Merck) and results are tabulated in Table 4. These results clearly show higher catalytic activity of predominant (111) facet CuO nanoparticles in N-arylation of azoles.

2.4. Effect of Catalyst Concentration

The effect of catalyst concentration on yield of product was studied. The reaction was carried out with varying amount of CuO catalyst concentration and results are tabulated in Table 5. As the concentration of catalyst was increased from 2.5 mol% to 5 mol%, the yield of the product was increased from 60% to 97% further increase in catalyst concentration did not affect overall yield of product.

2.5. Mechanism

The greater catalytic activity of CuO nanoparticles with respect to bulk CuO powder indicated that reactions were heterogeneous and occurred on the surface of predominant (111) facet nanocatalyst. Thus, the CuO nanoparticles might undergo reaction with aryl halide to give intermediate X, where the excess positive charge generated over iodine could be shared among the CuO nanoparticles present on the surface of the cluster (Scheme 3). Later, X might undergo reaction with triazole to give intermediate Y that can complete the catalytic cycle by the formation of the N-arylated product. The CuO nanoparticles become free at the end of reaction.

2.6. Recyclability of Catalyst

Finally, the stability and activity of the catalyst was tested in the recycle-use experiments. The CuO nanoparticles recycled for five times without loss of its catalytic activity (Table 6). The used catalyst was then separated by centrifugation and washed with hot water two-three times before being recycled in next reaction. It was found that during recycle experiments, there was not much loss in yield of the product which shows the recyclability and reusability of catalyst without significant loss of its catalytic activity.

3. Experimental Section

3.1. General Procedure for the N-Arylation of 1,2,4-Triazole

1,2,4-Triazole (3 mmol), iodobenzene (3.3 mmol), CuO nanoparticles (0.15 mmol), K₂CO₃ (3 mmol), and N–N dimethyl formamide (10 mL) were taken in a glass reactor. Stirred the reaction mixture at room temperature and monitored by Co-TLC till completion of reaction. After completion of reaction, dilute the reaction mixture with 20 mL water. The entire reaction mixture was washed with ethyl acetate ( mL). Aqueous layer was centrifuged to recover CuO nanocatalyst. The combined organic extracts were washed with brine and dried by sodium sulphate. Solvent was evaporated under reduced pressure and the crude product was purified by flash column chromatography on silica gel with ethyl acetate: petroleum ether (1 : 9) as eluent to yield analytically pure product.

1-Phenyl-1H-1,2,4-Triazole (1a)
Nature: light yellow oil. ¹H NMR 400 MHz (CDCl₃): δ 7.26 (s, 2H), 7.34 (s, 3H), 8.32 (d, Hz, 1H), 8.64 (s, 1H). ¹³C NMR 100 MHz (CDCl₃): δ 119.20, 123.25, 123.39, 129.34, 129.65, 135.18, 146.34. LCMS: .

1-(4-Nitrophenyl)-1H-1,2,4-Triazole (2a)
Nature: yellow solid, .¹H NMR 400 MHz (CDCl₃): δ 7.89–7.94 (m, 4H), 8.46 (s, 1H), 8.78 (s, 1H). ¹³C NMR 100 MHz (CDCl₃): δ 124.85, 130.35, 130.45, 138.65, 147.73, 154.71. LCMS: .

3.2. General Procedure for N-Arylation of Imidazole and Pyrazole

Azole (3 mmol), iodobenzene (3.3 mmol), CuO nanoparticles (0.15 mmol), K₂CO₃ (3 mmol), and N–N dimethyl formamide (10 mL) were taken in a glass reactor fitted with a condenser. Refluxed the mixture and monitored by Co-TLC, till completion of reaction. Workup procedure and purification of products were performed as described for the 1,2,4-triozole reactions.

1-P-Tolyl-1H-benzo[d]imidazole (1b)
Nature: oil, ¹H NMR 400 MHz (CDCl₃): δ 2.43 (s, 3H), 7.26–7.36 (m, 6H), 7.48 (d, Hz, 1H), 7.87 (d, Hz, 1H), 8.09 (s, 1H). ¹³C NMR 100 MHz (CDCl₃): δ 21.14, 110.53, 120.40, 122.79, 123.67, 124.00, 130.59, 133.67, 133.79, 138.21, 142.30, 143.58. LCMS: . IR (cm⁻¹) 3054, 3036, 1610, 1515, 1486, 1453, 1375, 1320, 1287, 1227, 1203, 1140, 1109, 1009, 976, 887, 818, 780, 764, 737, 708, 620, 586, 565.

1-Phenyl-1H-benzol[d][1,2,3]Triazole (2b)
Nature: white crystalline solid. °C. ¹H NMR 400 MHz (CDCl₃): δ (t, Hz, 1H), 7.49–7.57 (m, 2H), 7.61 (t, Hz, 2H), 7.75–7.80 (m, 3H), 8.15 (d, Hz, 1H). ¹³C NMR 100 MHz (CDCl₃): 110.39, 120.36, 122.91, 124.42, 128.26, 128.70, 129.89, 132.33, 137.02, 146.53. LCMS: . IR (KBr cm-1) 3098, 3040, 2918, 1655, 1595, 1560, 1500, 1458, 1290, 1275, 1244, 1188, 1143, 1126, 1089, 1059, 1010, 924, 785, 762, 708, 694, 659, 572, 517, 434.

1-Phenyl-1H-Imidazole (3b)
Nature: oil. ¹H NMR 400 MHz (CDCl₃): δ 7.26 (d, Hz, 1H), 7.30 (s, 1H), 7.41 (d, Hz, 3H), 7.51 (t, Hz, 2H), 8.05 (s, 1H). ¹³C NMR 100 MHz (CDCl₃): δ 118.53, 121.67, 127.97, 128.93, 130.01, 135.44, 136.99. LCMS .

1-Phenyl-1H-Pyrazole (4b)
Nature: oil. ¹H NMR 400 MHz (CDCl₃): δ 6.47 (s, 1H), 7.25–7.30 (m, 1H), 7.45 (t, Hz, 2H), 7.70 (t, Hz, 3H), 7.94 (s, 1H). ¹³C NMR 100 MHz (CDCl₃): δ 107.69, 115.41, 119.27, 120.30, 126.52, 126.91, 129.47, 129.59, 140.16, 141.10. LCMS .

4. Conclusion

A simple, general, and efficient procedure was described for N-arylation of 1,2,4-triazoles at room temperature with aryl iodides under ligand-free condition by the use of predominant (111) facet CuO nanoparticles as a catalyst. The catalyst was recyclable, and a variety of substrates undergo reaction in high yield. The wide scope of this catalyst led us to investigate transformations involving less-reactive azoles such as imidazole and pyrazole. We were pleased to found that various azole derivative effectively coupled with aryl iodide to afford the desired N-arylated products in excellent yields. See supplementary material available online at http://dx.doi.org/10.1155/2012/515092.

Acknowledgment

The authors gratefully acknowledge UGC, New Delhi (no. F-39-696/2010(SR) and F-14-11/2008 (inno./ASIST) for financial assistance to carry out this work through major research project and innovative programme.

Supplementary Materials

¹H NMR, ¹³C NMR, IR and LCMS of Azole derivatives are given. The ¹H NMR (400 MHz) chemical shifts were measured relative to CDCl₃ as the internal reference. The ¹³C NMR (100 MHz) chemical shifts are given using CDCl₃ as the internal standard. The LCMS were taken from ‘Shimatzu LCMS model no. 2010’.

Supplementary Material

References

Y. Kuwabara, H. Ogawa, H. Inada, N. Noma, and Y. Shirota, “Thermally stable multilayered organic electroluminescent devices using novel starburst molecules, 4,4′,4″-tri(N-carbazolyl)triphenylamine (TCTA) and 4,4′,4″-tris(3-methylphenylphenyl-amino)triphenylamine (m-MTDATA), as hole-transport materials,” Advanced Materials, vol. 6, no. 9, pp. 677–679, 1994.
View at: Google Scholar
N. X. Hu, S. Xie, Z. Popovic, B. Ong, A. M. Hor, and S. Wang, “5,11-dihydro-5,11-di-1-naphthylindolo[3,2-b]carbazole: atropisomerism in a novel hole-transport molecule for organic light-emitting diodes,” Journal of the American Chemical Society, vol. 121, no. 21, pp. 5097–5098, 1999.
View at: Publisher Site | Google Scholar
S. Maiorana, C. Baldoli, P. Del Buttero, M. Di Ciolo, and A. Papagni, “Aromatic nucleophilic substitution on haloarene chromium tricarbonyl complexes: mild N-arylation on indoles,” Synthesis, no. 5, pp. 735–738, 1998.
View at: Google Scholar
A. Kiyomori, J. F. Marcoux, and S. L. Buchwald, “An efficient copper-catalyzed coupling of aryl halides with imidazoles,” Tetrahedron Letters, vol. 40, no. 14, pp. 2657–2660, 1999.
View at: Publisher Site | Google Scholar
W. J. Smith and J. S. Sawyer, “A novel and selective method for the N-arylation of indoles mediated by KF/Al2O3,” Tetrahedron Letters, vol. 37, no. 3, pp. 299–302, 1996.
View at: Publisher Site | Google Scholar
I. P. Beletskaya, D. V. Davydov, and M. Moreno-Mañas, “Pd- and Cu-catalyzed selective arylation of benzotriazole,” Tetrahedron Letters, vol. 39, no. 31, pp. 5617–5620, 1998.
View at: Publisher Site | Google Scholar
G. Mann, J. F. Hartwig, M. S. Driver, and C. F. Rivas, “Palladium-catalyzed C−N(sp²) bond formation: N-Arylation of aromatic and unsaturated nitrogen and the reductive elimination chemistry of palladium azolyl and methyleneamido complexes,” Journal of the American Chemical Society, vol. 120, pp. 827–828, 1998.
View at: Publisher Site | Google Scholar
K. Prabakaran, P. Manivel, and F. Nawaz Khan, “An effective BINAP and microwave accelerated palladium-catalyzed amination of 1-chloroisoquinolines in the synthesis of new 1,3-disubstituted isoquinolines,” Tetrahedron Letters, vol. 51, no. 33, pp. 4340–4343, 2010.
View at: Publisher Site | Google Scholar
A. Klapars, J. C. Antilla, X. Huang, and S. L. Buchwald, “A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles,” Journal of the American Chemical Society, vol. 123, no. 31, pp. 7727–7729, 2001.
View at: Publisher Site | Google Scholar
J. D. Hicks, A. M. Hyde, A. M. Cuezva, and S. L. Buchwald, “Pd-catalyzed N-arylation of secondary acyclic amides: Catalyst development, scope, and computational study,” Journal of the American Chemical Society, vol. 131, no. 46, pp. 16720–16734, 2009.
View at: Publisher Site | Google Scholar
M. Kim and S. Chang, “Rhodium(NHC)-catalyzed amination of aryl bromides,” Organic Letters, vol. 12, pp. 1640–1643, 2010.
View at: Publisher Site | Google Scholar
R. Omar-Amrani, A. Thomas, E. Brenner, R. Schneider, and Y. Fort, “Efficient nickel-mediated intramolecular amination of aryl chlorides,” Organic Letters, vol. 5, no. 13, pp. 2311–2314, 2003.
View at: Publisher Site | Google Scholar
P. F. Larsson, A. Correa, M. Carril, P. O. Norrby, and C. Bolm, “Copper-catalyzed cross-couplings with part-per-million catalyst loadings,” Angewandte Chemie, vol. 48, no. 31, pp. 5691–5693, 2009.
View at: Publisher Site | Google Scholar
A. Shafir and S. L. Buchwald, “Highly selective room-temperature copper-catalyzed C–Ncoupling reactions,” Journal of the American Chemical Society, vol. 128, pp. 8742–8743, 2006.
View at: Publisher Site | Google Scholar
J. C. Antilla, J. M. Baskin, T. E. Barder, and S. L. Buchwald, “Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles,” Journal of Organic Chemistry, vol. 69, no. 17, pp. 5578–5587, 2004.
View at: Publisher Site | Google Scholar
H. B. Goodbrand and N. X. Hu, “Ligand-accelerated catalysis of the Ullmann condensation: application to hole conducting triarylamines,” The Journal of Organic Chemistry, vol. 64, pp. 670–674, 1999.
View at: Publisher Site | Google Scholar
R. Gujadhur, D. Venkataraman, and J. T. Kintigh, “Formation of aryl-nitrogen bonds using a soluble copper(I) catalyst,” Tetrahedron Letters, vol. 42, no. 29, pp. 4791–4793, 2001.
View at: Publisher Site | Google Scholar
D. W. Ma, Q. Cai, and H. Zhang, “Mild method for Ullmann coupling reaction of amines and aryl halides,” Organic Letters, vol. 5, pp. 2453–2455, 2003.
View at: Publisher Site | Google Scholar
H. Kaddouri, V. Vicente, A. Ouali, F. Ouazzani, and M. Taillefer, “Copper-catalyzed arylation of nucleophiles by using butadienylphosphines as ligands: mechanistic insight,” Angewandte Chemie, vol. 48, no. 2, pp. 333–336, 2009.
View at: Publisher Site | Google Scholar
E. Haldón, E. Alvarez, M. Carmen Nicasio, and P. J. Pérez, “Dinuclear copper(I) complexes as precatalysts in Ulimann and Goldberg coupling reactions,” Organometallics, vol. 28, no. 13, pp. 3815–3821, 2009.
View at: Publisher Site | Google Scholar
K. Okano, H. Tokuyama, and T. Fukuyama, “Synthesis of secondary arylamines through copper-mediated intermolecular aryl amination,” Organic Letters, vol. 5, no. 26, pp. 4987–4990, 2003.
View at: Publisher Site | Google Scholar
A. Correa and C. Bolm, “Ligand-Free copper-catalyzed N-arylation of nitrogen nucleophiles,” Advanced Synthesis & Catalysis, vol. 349, pp. 2673–2676, 2007.
View at: Publisher Site | Google Scholar
M. Taillefer, N. Xia, and A. Ouali, “Efficient iron/copper co-catalyzed arylation of nitrogen nucleophiles,” Angewandte Chemie, vol. 46, no. 6, pp. 934–936, 2007.
View at: Publisher Site | Google Scholar
Z. J. Liu, J. P. Vors, E. R. F. Gesing, and C. Bolm, “Microwave-assisted solvent- and ligand-free copper-catalysed cross-coupling between halopyridines and nitrogen nucleophiles,” Green Chemistry, vol. 13, no. 1, pp. 42–45, 2011.
View at: Publisher Site | Google Scholar
B. M. Choudary, C. Sridhar, M. L. Kantam, G. T. Venkanna, and B. Sreedhar, “Design and evolution of copper apatite catalysts for N-arylation of heterocycles with chloro- and fluoroarenes,” Journal of the American Chemical Society, vol. 127, no. 28, pp. 9948–9949, 2005.
View at: Publisher Site | Google Scholar
L. Rout, T. K. Sen, and T. Punniyamurthy, “Efficient CuO-nanoparticle-catalyzed C-S cross-coupling of thiols with iodobenzene,” Angewandte Chemie, vol. 46, no. 29, pp. 5583–5586, 2007.
View at: Publisher Site | Google Scholar
L. Rout, S. Jammi, and T. Punniyamurthy, “Novel CuO nanoparticle catalyzed C–N cross coupling of amines with Lodobenzene,” Organic Letters, vol. 9, no. 17, pp. 3397–3399, 2007.
View at: Publisher Site | Google Scholar
M. Kidwai, S. Bhardwaj, and R. Poddar, “C-arylation reactions catalyzed by CuO-nanoparticles under ligand free conditions,” Beilstein Journal of Organic Chemistry, vol. 6, article no. 35, 2010.
View at: Publisher Site | Google Scholar
P. Larsson and A. Andersson, “Complete oxidation of CO, ethanol, and ethyl acetate over copper oxide supported on titania and ceria modified titania,” Journal of Catalysis, vol. 179, pp. 72–89, 1998.
View at: Publisher Site | Google Scholar
B. Raveau, C. Michel, M. Herview, and D. Groult, Superconducting Copper Oxide, Springer, Berlin, Germany, 1991.
Y. Liu, Q. Fu, and M. F. Stephanopoulos, “Preferential oxidation of CO in H₂ over CuO-CeO₂ catalysts,” Catalysis Today, vol. 93-95, pp. 241–246, 2004.
View at: Publisher Site | Google Scholar
A. A. Martinez, A. B. Hungria, M. Fernandez-Garcia, J. C. Conesa, and J. C. Munuera, “Interfacial Redox processes under CO/O₂ in a Nanoceria-supported copper oxide catalyst,” The Journal of Physical Chemistry B, vol. 108, pp. 17983–17991, 2004.
View at: Publisher Site | Google Scholar
M. L. Kantam, S. Laha, J. Yadav, P. R. Likhar, B. Sreedhar, and B. M. Choudary, “Asymmetric hydrosilylation of prochiral ketones catalyzed by nanocrystalline copper(II) oxide,” Advanced Synthesis and Catalysis, vol. 349, no. 10, pp. 1797–1802, 2007.
View at: Publisher Site | Google Scholar
M. L. Kantam, T. Ramani, L. Chakrapani, and K. V. Kumar, “Direct asymmetric aldol reactions catalyzed by nanocrystalline copper(II) oxide,” Tetrahedron Letters, vol. 49, no. 9, pp. 1498–1501, 2008.
View at: Publisher Site | Google Scholar
N. V. Suramwar, S. R. Thakare, N. N. Karade, and N. T. Khaty, “Green synthesis of predominant (1 1 1) facet CuO nanoparticles: Heterogeneous and recyclable catalyst for N-arylation of indoles,” Journal of Molecular Catalysis A, vol. 359, pp. 28–34, 2012.
View at: Publisher Site | Google Scholar
D. Wang, F. Zhang, D. Kuang, J. Yu, and J. Li, “A highly efficient Cu-catalyst system for N-arylation of azoles in water,” Green Chemistry, vol. 14, no. 5, pp. 1268–1271, 2012.
View at: Publisher Site | Google Scholar

Copyright

Copyright © 2012 Nikhil V. Suramwar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation

Download other formats

Order printed copies

Views

3652

Downloads

1496

Citations