Research Article
Development and Validation of Dissolution Test for Fluconazole Capsules by HPLC and Derivative UV Spectrophotometry
Table 3
Validation parameters for different analytical methods, UV-FDS and HPLC, to determine fluconazole in capsules.
| | Parameters | FDS | HPLC |
| | Analytical curve | | | | Intercept values | −2.9 × 10−3 | −1.1 × 104 | | Standard error of slope | 8.8346 × 10−7 | 19.63 | | Correlation coefficient () | 0.998 | 0.996 | | R.S.D. of repeatability (%) | 0.75 | 0.81 | | R.S.D. intermediate (%) | 2.55 | 2.29 | | Accuracy (%) | 98.35 | 98.56 | | R.S.D. of accuracy (%) | 0.88 | 0.82 | | LOQ | 4.9 × 10−3 | 1.28 × 10−8 | | LOD | 1.4 × 10−3 | 3.84 × 10−9 |
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