Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain

<table>Influence of ascorbic acid and rotenone on the Ca<sup>2+</sup> release from HEp-2 cells mitochondria under the antimycin A treatment. Concentrations in KRH: ascorbic acid—5 mM, antimycin A—10 <i>μ</i>M, rotenone—50 <i>μ</i>M. Number of cells in 1 mL—3 <svg height="8.5" id="M13" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 8.5" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> 10<sup>6</sup>. Arrows show the instants of antimycin A (AmA), ascorbic acid (Asc), and rotenone (Rot) addition. The inset shows dependence of increase in <svg height="22.975" id="M14" style="vertical-align:-5.73166pt" version="1.1" viewbox="0 0 59.025002 22.975" width="59.025002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> on the antimycin A concentration.</table>

Journal of Biophysics

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Figure 3

Figure 3: Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain 