Research Article

Chronic Nonhealing Wounds: Could Leg Ulcers Be Hereditary?

Figure 1

Rare allele frequencies of the 2451 A/G SNP of FGFR2 and the −308 A/G SNP of TNFA in the subgroups of VLU patients. The FGFR2 3′UTR 2451A/G polymorphism exhibited similar distributions among the subgroups of VLU patients, suggesting an overall role of susceptibility in the disease development. Our data also demonstrated that the homozygous rare allele of the −308 TNFA SNP occurred significantly higher among VLU patients without additional acquired predisposing factors in their history (group A) than among patients with other known etiological events in their history (group C; group A versus group C Fisher exact probability test, ).
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