Cardiovascular Psychiatry and Neurology

Clinical Study

Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database

Table 6

RR of all-cause mortality (excluding suicide) or cardiac mortality in users of atypical and typical antipsychotics.


Outcome	Type of antipsychotic	No. of cases	Incidence rate per 1000 person-years	Age, sex-adjusted relative risk (RR) (95% CI)	Fully adjusted RR (aRR) (95% CI)

All-cause mortality	Typical	15,334	91.5	Reference	Reference
All-cause mortality	Atypical	7,555	76.0	0.79 (0.77–0.81)^‡	0.83 (0.80–0.85)^‡
Cardiac mortality	Typical	1,130	17.8	Reference	Reference
Cardiac mortality	Atypical	1,214	16.1	0.84 (0.78–0.91)^‡	0.89 (0.82–0.97)^‡
SCD primary definition	Typical	20	3.8	Reference	Reference
SCD primary definition	Atypical	22	2.1	—(NC^#)	—(NC^#)
SCD secondary definition	Typical	77	14.5	Reference	Reference
SCD secondary definition	Atypical	95	9.1	0.72 (0.53–0.97)^†	0.76 (0.55–1.04)*
SCD tertiary definition	Typical	97	6.3	Reference	Reference
SCD tertiary definition	Atypical	99	3.7	0.66 (0.50–0.87)^‡	0.70 (0.53–0.93)^†
CHD	Typical	867	6.3	Reference	Reference
CHD	Atypical	459	5.1	0.80 (0.72–0.90)^‡	0.85 (0.76–0.96)^‡
Ventricular arrhythmias	Typical	382	2.8	Reference	Reference
Ventricular arrhythmias	Atypical	242	2.7	0.94 (0.80–1.10)	0.93 (0.79–1.10)

, ^†, ^‡, ^#Not calculable due to small number of cases.