Research Article

Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations

Table 7

LOD, LOQ, and precision data.

CompoundLOD (%)LOQ (%)S/N ratio% RSD at LOQ Level precision
LODLOQ

GN-Impurity A0.0040.0012.79.54.2
GN-Impurity B0.0080.0022.99.82.5
GN-Impurity C0.0050.0023.09.83.1
GN-Impurity D0.0030.0012.99.72.5
DN-Impurity A0.0140.0042.810.11.1
DN-Impurity B0.0210.0062.710.43.4
DN-Impurity C0.0230.0072.89.94.9
DN-N-oxide0.0160.0053.19.82.2
DN-NFM Impurity0.0160.0052.710.11.5
DN-NFO Impurity0.0410.0122.910.64.2
GN0.0060.0023.19.82.1
DN0.0150.0052.89.62.8