Chromatography Research International / 2013 / Article / Tab 7 / Research Article
Development and Validation of a Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Guaifenesin and Dextromethorphan Impurities in Pharmaceutical Formulations Table 7 LOD, LOQ, and precision data.
Compound LOD (%) LOQ (%) S/N ratio % RSD at LOQ Level precision LOD LOQ GN-Impurity A 0.004 0.001 2.7 9.5 4.2 GN-Impurity B 0.008 0.002 2.9 9.8 2.5 GN-Impurity C 0.005 0.002 3.0 9.8 3.1 GN-Impurity D 0.003 0.001 2.9 9.7 2.5 DN-Impurity A 0.014 0.004 2.8 10.1 1.1 DN-Impurity B 0.021 0.006 2.7 10.4 3.4 DN-Impurity C 0.023 0.007 2.8 9.9 4.9 DN-N-oxide 0.016 0.005 3.1 9.8 2.2 DN-NFM Impurity 0.016 0.005 2.7 10.1 1.5 DN-NFO Impurity 0.041 0.012 2.9 10.6 4.2 GN 0.006 0.002 3.1 9.8 2.1 DN 0.015 0.005 2.8 9.6 2.8