Research Article
Neurological Adverse Effects in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX
Table 3
Comparative differences in frequency of grade 3 neurological adverse effects with grade 1 and grade 2 adverse effects.
| | Paired samples test | | Toxicity | Mean | Std. deviation | Mean difference | t | df | P value |
| | Taste disturbance grade 1, 2 | 3.816 | 3.525 | 3.789 | 6.608 | 37.000 | 0.000 | | Taste disturbance grade 3 | 0.026 | 0.162 | | Headache grade 1, 2 | 2.053 | 2.588 | 2.053 | 4.888 | 37.000 | 0.000 | | Headache grade 3 | 0.000 | 0.000 | | Paresthesia grade 1, 2 | 5.079 | 3.529 | 5.079 | 8.872 | 37.000 | 0.000 | | Paresthesia grade 3 | 0.000 | 0.000 | | Dizziness grade 1, 2 | 1.474 | 2.345 | 1.474 | 3.874 | 37.000 | 0.000 | | Dizziness grade 3 | 0.000 | 0.000 | | Insomnia grade 1, 2 | 1.474 | 2.357 | 1.474 | 3.855 | 37.000 | 0.000 | | Insomnia grade 3 | 0.000 | 0.000 | | Peripheral neuropathy grade 1, 2 | 4.947 | 3.385 | 4.395 | 7.045 | 37.000 | 0.000 | | Peripheral neuropathy grade 3 | 0.553 | 1.589 | | Hypoaesthesia grade 1, 2 | 4.526 | 4.105 | 4.526 | 6.797 | 37.000 | 0.000 | | Hypoaesthesia grade 3 | 0.000 | 0.000 |
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P value < 0.05 (significant), P value < 0.01 (highly significant), and P value < 0.001 (very highly significant).
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