Review Article
SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective
Table 2
Active site shape and volume for PPAR
γ agonists (see Figure
5).
| | PDB | Ligand | Active site shape | Active site volume |
| | 2PRG | RGZ (A) | Y | 1703 Å3 | | 2PRG | PGZ (B) | Y | 1703 Å3 | | 2PRG | Barbituric acid analogue (C) | Y | 1703 Å3 | | 2Q59 | MRL20 (D) | L | 1407 Å3 | | 1FM9 | Farglitazar (E) | μ | 1815 Å3 | | 3CDP | Clofibric acid analogue (F) | μ | 1598 Å3 | | 2Q5P | MRL24 (G) | L | 1218 Å3 | | 2Q6S | BVT.13 (H) | L | 1568 Å3 |
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