Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form
Table 2
Robustness study of CPM, IBU, and PHE.
Method parameter/condition
Deliberate changes
% RSD of peak area ()
CPM
IBU
PHE
Flow rate
0.9 mL/min
0.89
1.26
1.63
1.1 mL/min
1.23
1.39
1.73
Mobile phase ratio Acetonitrile : methanol : phosphate buffer
